Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508226 | 0.80 | HAO1 (0.37) | HAO1CARM1PRMT6CRHR1ACHE | |
| SCHEMBL5706341 | 0.78 | PTGES (0.44) | HAO1PTGESKMT2AACACB | |
| SCHEMBL15576247 | 0.75 | TSHR (0.41) | HAO1CARM1PRMT6ACHEBACE1 | |
| SCHEMBL3130734 | 0.72 | TSHR (0.41) | HAO1KMT2ATSHR | |
| SCHEMBL25823674 | 0.70 | TSHR (0.40) | HAO1KMT2ATSHR | |
| SCHEMBL4513973 | 0.69 | FFAR1 (0.56) | HAO1CRHR1PTGESKMT2AACACB | |
| SCHEMBL1419784 | 0.68 | PRKCQ (0.48) | CARM1PRMT6CRHR1KMT2APOLB | |
| SCHEMBL632625 | 0.68 | POLB (0.60) | CRHR1KMT2ATSHRPOLBPRKCQ | |
| SCHEMBL4369018 | 0.68 | CRHR1 (0.52) | CRHR1KMT2A | |
| SCHEMBL25547612 | 0.68 | CRHR1 (0.41) | CARM1PRMT6CRHR1ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696899-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058301-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2005-06-30 | — | — | WO | disclosed |