Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 6/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4513889 | 0.81 | DPP4 (0.46) | DPP4DPP9DPP7GRIN2BPTGES | |
| SCHEMBL4514422 | 0.80 | DPP4 (0.47) | DPP4DPP9DPP7GRIN2BPTGES | |
| SCHEMBL5706324 | 0.77 | HRH3 (0.40) | DPP4DPP9DPP7GRIN2BHRH4 | |
| SCHEMBL5706358 | 0.75 | JAK1 (0.34) | — | |
| SCHEMBL4523863 | 0.71 | FFAR1 (0.53) | PTGESSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4523880 | 0.71 | FFAR1 (0.53) | PTGESSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5706341 | 0.71 | PTGES (0.44) | PTGES | |
| SCHEMBL4169205 | 0.71 | SIGMAR1 (0.49) | DPP4DPP9DPP7GRIN2BHRH4 | |
| SCHEMBL13232926 | 0.71 | SLC6A3 (0.57) | DPP4DPP9DPP7GRIN2BHRH4 | |
| SCHEMBL4521338 | 0.70 | PTGES (0.45) | DPP4DPP9DPP7PTGESSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696899-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058301-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2005-06-30 | — | — | WO | disclosed |