Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17322362 | 0.77 | NFE2L2 (0.38) | HDAC6NFE2L2POLBKDM4EL3MBTL1 | |
| SCHEMBL29377776 | 0.76 | NFE2L2 (0.36) | HDAC6NFE2L2POLBKDM4EL3MBTL1 | |
| SCHEMBL69571 | 0.76 | NFE2L2 (0.36) | HDAC6NFE2L2POLBKDM4EL3MBTL1 | |
| SCHEMBL15944537 | 0.71 | NFE2L2 (0.33) | HDAC6NFE2L2POLBKDM4EL3MBTL1 | |
| SCHEMBL15334372 | 0.68 | NFE2L2 (0.34) | HDAC6NFE2L2POLBKDM4EL3MBTL1 | |
| SCHEMBL7642605 | 0.66 | POLB (0.35) | HDAC6NFE2L2POLBKDM4EL3MBTL1 | |
| SCHEMBL19102454 | 0.65 | ADRA2A (0.41) | FDPSFDFT1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16838713 | 0.65 | ADK (0.43) | L3MBTL1PTK2 | |
| SCHEMBL14339841 | 0.64 | PTK2 (0.39) | HDAC6NFE2L2FDPSFDFT1L3MBTL1 | |
| SCHEMBL28028214 | 0.62 | ADRA2A (0.35) | NFE2L2FDPSFDFT1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696899-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058301-A1 | METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B | ALLERGAN, INC. (US) | 2005-06-30 | — | — | WO | disclosed |