SCHEMBL570739

SCHEMBL570739

O=C(c1ccccc1)c1ccc(Br)c(Br)c1C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 3/20 0.55
KDM4E B2RXH2 1/20 0.47
MYC P01106 1/20 0.45
ALDH1A1 P00352 1/20 0.45
MAPT P10636 2/20 0.45
POLB P06746 1/20 0.45
CDC25B P30305 2/20 0.44
CDC25A P30304 1/20 0.44
HSD17B10 Q99714 1/20 0.44
ATM Q13315 1/20 0.44
SRD5A2 P31213 1/20 0.44
GAA P10253 2/20 0.43
NR4A1 P22736 1/20 0.43
CYP2C8 P10632 1/20 0.43
CYP2C9 P11712 1/20 0.43
MEN1 O00255 1/20 0.43
USP2 O75604 1/20 0.43
KMT2A Q03164 1/20 0.43
KEAP1 Q14145 1/20 0.43
NFE2L2 Q16236 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7931235 0.83 ALDH1A1 (0.50) AKR1C3KDM4EALDH1A1MAPTPOLB
SCHEMBL195812 0.81 CYP1A2 (0.44) AKR1C3KDM4EALDH1A1CDC25BCDC25A
SCHEMBL809324 0.79 AKR1C3 (0.72) AKR1C3KDM4EMYCALDH1A1MAPT
SCHEMBL1666651 0.78 ALDH1A1 (0.65) AKR1C3KDM4EMYCALDH1A1MAPT
SCHEMBL6057040 0.77 AKR1C3 (0.69) AKR1C3KDM4EMYCALDH1A1MAPT
SCHEMBL6056938 0.77 AKR1C3 (0.69) AKR1C3KDM4EMYCALDH1A1MAPT
SCHEMBL6597786 0.76 AKR1C3 (0.55) AKR1C3ALDH1A1MAPTPOLBCDC25B
SCHEMBL29683548 0.76 AKR1C3 (0.55) AKR1C3ALDH1A1MAPTPOLBCDC25B
SCHEMBL163745 0.74 AKR1C3 (0.59) AKR1C3KDM4EMYCALDH1A1MAPT
SCHEMBL1129191 0.74 PRNP (0.59) AKR1C3KDM4EALDH1A1MAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012017977-A1 NOVEL ORGANIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING SAME CANON KABUSHIKI KAISHA (JP) 2012-02-09 WO disclosed