Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 3/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11156080 | 0.83 | TYR (0.46) | HSD17B3TYRESR1ESR2MEN1 | |
| SCHEMBL28425995 | 0.79 | TYR (0.61) | TYRESR1ESR2MEN1TP53 | |
| SCHEMBL30979257 | 0.78 | TYR (0.48) | HSD17B3TYRHSP90AB1GABRA1GABRB2 | |
| SCHEMBL1724358 | 0.78 | TYR (0.48) | HSD17B3TYRHSP90AB1GABRA1GABRB2 | |
| SCHEMBL27890375 | 0.77 | TYR (0.34) | TYRESR1ESR2MAPTTDP1 | |
| SCHEMBL8396510 | 0.77 | TYR (0.35) | TYRESR1ESR2MEN1TP53 | |
| SCHEMBL11553663 | 0.77 | ALOX5 (0.64) | TYRESR1MEN1TP53CYP3A4 | |
| SCHEMBL11159610 | 0.77 | ALOX5 (0.64) | TYRESR1MEN1TP53CYP3A4 | |
| SCHEMBL1972040 | 0.76 | GABRA1 (0.32) | GABRA1GABRB2MAPT | |
| SCHEMBL29531568 | 0.76 | ANPEP (0.49) | HSD17B3TYRHSP90AB1GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706386-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066136-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |