Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.61 |
| ▸ | SCN1A | P35498 | 4/20 | 0.61 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.61 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | DRD1 | P21728 | 5/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.59 |
| ▸ | HTR2A | P28223 | 4/20 | 0.59 |
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.59 |
| ▸ | HRH2 | P25021 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promethazine SCHEMBL11737862 | 0.93 | CHRM2 (0.65) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Promethazine SCHEMBL28086705 | 0.83 | CYP2D6 (0.64) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Isothipendyl SCHEMBL2556455 | 0.82 | LMNA (0.64) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Isothipendyl SCHEMBL507004 | 0.81 | LMNA (0.63) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Pheniramine SCHEMBL48720 | 0.78 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Pheniramine SCHEMBL30182646 | 0.78 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Pheniramine SCHEMBL4796 | 0.78 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Pheniramine SCHEMBL126153 | 0.78 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Pheniramine SCHEMBL18240052 | 0.77 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| Pheniramine SCHEMBL365145 | 0.77 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706089-A1 | DERMATOLOGIC SOFT GEL COMPOSITIONS | STIEFEL LABORATORIES, INC. (US) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005072686-A1 | DERMATOLOGIC SOFT GEL COMPOSITIONS | STIEFEL LABORATORIES, INC. (US) | 2005-08-11 | — | — | WO | disclosed |
| US-20050158377-A1 | Dermatologic soft gel compositions | STIEFEL LABORATORIES, INC. | 2005-07-21 | — | — | US | disclosed |