Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5709202 | 0.73 | HDAC8 (0.40) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL28223520 | 0.70 | HRAS (0.36) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL4855585 | 0.69 | HRAS (0.50) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL4850168 | 0.68 | HRAS (0.49) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL6130558 | 0.66 | — | — | |
| SCHEMBL20448741 | 0.66 | — | — | |
| SCHEMBL28026875 | 0.65 | ALDH1A1 (0.40) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL14002822 | 0.63 | TOP1 (0.62) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL5748174 | 0.63 | TOP1 (0.62) | HRASESR1TOP1ESR2KDM4E | |
| SCHEMBL5745871 | 0.63 | TOP1 (0.62) | HRASESR1TOP1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641753-B1 | PROCESS FOR THE SYNTHESIS OF DISTAMYCIN AND DERIVATIVES THEREOF USING 1-METHYL-4-FORMYLAMINO-2-PYRROLECARBONYL CHLORIDE ITERATIVELY AS AN INTERMEDIATE | NAXOSPHARMA S R L (IT) | 2006-10-18 | — | — | EP | claimed |