Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.55 |
| ▸ | TNKS | O95271 | 1/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.55 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 7/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11415463 | 1.00 | HDAC3 (0.55) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Fumaric Acid SCHEMBL11411218 | 1.00 | HDAC3 (0.55) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Bicarbonate SCHEMBL16751853 | 0.91 | MAOB (0.54) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Juarezic Acid SCHEMBL15064809 | 0.89 | HDAC3 (0.47) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Acrylic Acid SCHEMBL237879 | 0.88 | MAOB (0.47) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Acrylic Acid SCHEMBL1720420 | 0.88 | MAOB (0.47) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL679380 | 0.87 | MAOB (0.64) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL17741 | 0.87 | MAOB (0.64) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Benzene SCHEMBL28245201 | 0.87 | MAOB (0.64) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| Acrylic Acid SCHEMBL25421985 | 0.87 | MAOB (0.45) | HDAC3HDAC4HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107501890-A | A kind of PC/ABS alloys heat conductive insulating nano composite material and preparation method thereof | 武汉光盛电气有限公司 | 2017-12-22 | — | — | CN | claimed |
| CN-104592613-B | Extrusion grade foaming PP/PE materials and preparation method thereof | 广东技塑新材料股份有限公司 | 2017-10-17 | — | — | CN | claimed |
| CN-111511831-B | Scratch-resistant styrenic copolymer compositions containing nanoparticles of inorganic metal compounds | 英力士苯领集团股份公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-111511831-A | Scratch resistant styrenic copolymer compositions containing inorganic metal compound nanoparticles | 英力士苯领集团股份公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-108623929-A | A kind of dedicated impact-resistant polystyrene material of refrigerator and preparation method thereof | 合肥杰事杰新材料股份有限公司 | 2018-10-09 | — | — | CN | disclosed |
| CN-106189111-B | A kind of optical fiber jacket material and preparation method thereof | 南京华信藤仓光通信有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-107722484-A | Composition of photodiffusion material and preparation method thereof | 中山市华塑塑胶科技有限公司 | 2018-02-23 | — | — | CN | disclosed |
| CN-107501890-A | A kind of PC/ABS alloys heat conductive insulating nano composite material and preparation method thereof | 武汉光盛电气有限公司 | 2017-12-22 | — | — | CN | disclosed |
| CN-107459807-A | A kind of PPO/LCP/PET ternary-alloy materials and preparation method thereof | 广东壹豪新材料科技股份有限公司 | 2017-12-12 | — | — | CN | disclosed |
| EP-1711560-A1 | THERMOPLASTIC MOULDING MASSES MADE FROM STYROL COPOLYMERS AND POLYAMIDES | BASF AKTIENGESELLSCHAFT (DE) | 2006-10-18 | — | — | EP | disclosed |
| EP-1611202-A1 | METHOD FOR PRODUCING THERMOPLASTIC MOLDING MATERIALS | BASF Aktiengesellschaft (DE) | 2006-01-04 | — | — | EP | disclosed |
| CN-1055099-C | Styrene resin composition | QIMEI IND CO LTD (CN) | 2000-08-02 | — | — | CN | disclosed |
| CN-1048268-C | Rubber modified styrene resin composition | QIMEI IND CO LTD (CN) | 2000-01-12 | — | — | CN | disclosed |
| CN-1201052-A | Phenylethylene series resin composite | QIMEI IND CO LTD (CN) | 1998-12-09 | — | — | CN | disclosed |
| CN-1182757-A | Phenylethylene resin composition | QIMEI COMMERCIAL AND IND CO LT (CN) | 1998-05-27 | — | — | CN | disclosed |
| CN-1174858-A | Flame-retarded phenylethylene series resin composition | QIMEI IND AND COMMERCIAL CO LT (CN) | 1998-03-04 | — | — | CN | disclosed |
| CN-1172130-A | Phenylethylene resin composition | QIMEI IND CO LTD (CN) | 1998-02-04 | — | — | CN | disclosed |
| CN-1147529-A | Rubber modified styrene resin composition | QIMEI IND CO LTD (CN) | 1997-04-16 | — | — | CN | disclosed |
| US-4181788-A | Process for the production of thermoplastic molding materials based on vinyl polymers | BAYER AKTIENGESELLSCHAFT (DE) | 1980-01-01 | — | — | US | disclosed |
| US-4141934-A | MULTISTAGE, THERMOPLASTIC STYRENE COPOLYMER MOLDING MATERIALS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-02-27 | — | — | US | disclosed |