Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27680727 | 1.00 | HSD11B1 (0.39) | HSD11B1ALDH1A1P2RX7BACE1PRMT5 | |
| SCHEMBL5709379 | 1.00 | HSD11B1 (0.39) | HSD11B1ALDH1A1P2RX7BACE1PRMT5 | |
| SCHEMBL27660700 | 0.90 | HSD11B1 (0.42) | HSD11B1ALDH1A1AKR1B1DGAT1SRD5A1 | |
| SCHEMBL5709364 | 0.90 | HSD11B1 (0.42) | HSD11B1ALDH1A1AKR1B1DGAT1SRD5A1 | |
| SCHEMBL27680729 | 0.90 | HSD11B1 (0.42) | HSD11B1ALDH1A1AKR1B1DGAT1SRD5A1 | |
| SCHEMBL5709378 | 0.85 | HSD11B1 (0.41) | HSD11B1ALDH1A1P2RX7AKR1B1 | |
| SCHEMBL5709361 | 0.83 | HSD11B1 (0.43) | HSD11B1ALDH1A1AKR1B1DGAT1SRD5A1 | |
| SCHEMBL27680726 | 0.83 | HSD11B1 (0.43) | HSD11B1ALDH1A1AKR1B1DGAT1SRD5A1 | |
| SCHEMBL27680705 | 0.83 | HSD11B1 (0.43) | HSD11B1ALDH1A1AKR1B1DGAT1SRD5A1 | |
| SCHEMBL5709374 | 0.82 | SLC6A2 (0.47) | HSD11B1ALDH1A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1950328-A | Phenyl indan derivatives | LUNDBECK & CO AS H (DK) | 2007-04-18 | — | — | CN | disclosed |
| EP-1727785-A1 | PHENYL INDAN DERIVATIVES | H.Lundbeck A/S (DK) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005087708-A1 | PHENYL INDAN DERIVATIVES | H. LUNDBECK A/S (DK) | 2005-09-22 | — | — | WO | disclosed |