⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5709682 | 0.96 | — | — | |
| SCHEMBL25357257 | 0.92 | — | — | |
| SCHEMBL5037562 | 0.89 | INMT (0.40) | — | |
| SCHEMBL19856449 | 0.89 | — | — | |
| SCHEMBL1826475 | 0.89 | INMT (0.40) | — | |
| SCHEMBL1824179 | 0.86 | USP2 (0.44) | — | |
| SCHEMBL28615280 | 0.86 | USP2 (0.44) | — | |
| SCHEMBL1828720 | 0.86 | USP2 (0.44) | — | |
| SCHEMBL206437 | 0.86 | USP2 (0.44) | — | |
| SCHEMBL17317854 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116640157-A | METTL3 inhibitor and composition thereof and application of METTL3 inhibitor and composition thereof in medicine | 海思科医药集团股份有限公司 | 2023-08-25 | — | — | CN | claimed |
| WO-2023151697-A1 | METTL3 INHIBITOR AND COMPOSITION, AND APPLICATION OF SAME IN MEDICINE | 四川海思科制药有限公司 | 2023-08-17 | — | — | WO | claimed |
| WO-2023088425-A1 | 15-PGDH INHIBITOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2023-05-25 | — | — | WO | claimed |
| CN-116135856-A | 15-PGDH inhibitor and application thereof | 武汉人福创新药物研发中心有限公司 | 2023-05-19 | — | — | CN | claimed |
| EP-3983069-A1 | MODULATORS OF TMEM16A FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2022-04-20 | — | — | EP | claimed |
| CN-114269433-A | Modulators of TMEM16A for the treatment of respiratory diseases | TMEM16A有限公司 | 2022-04-01 | — | — | CN | claimed |
| WO-2020249956-A1 | MODULATORS OF TMEM16A FOR TREATING RESPIRATORY DISEASE | Enterprise Therapeutics Limited (GB) | 2020-12-17 | — | — | WO | claimed |
| EP-3626239-B1 | EZH2 INHIBITOR COMBINED WITH BTK INHIBITOR FOR TREATING TUMOR | JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN) | 2024-07-03 | — | — | EP | disclosed |
| US-20240101566-A1 | TRICYCLIC UBIQUITIN SPECIFIC PROTEASE 1 INHIBITOR AND USE THEREOF | Xuanzhu Biopharmaceutical Co., Ltd. (CN) | 2024-03-28 | — | — | US | disclosed |
| EP-4335852-A1 | TRICYCLIC UBIQUITIN SPECIFIC PROTEASE 1 INHIBITOR AND USE THEREOF | Shandong Xuanzhu Pharma Co., Ltd. (CN) | 2024-03-13 | — | — | EP | disclosed |
| WO-2024032661-A1 | KIF18A INHIBITOR AND USE THEREOF | 山东轩竹医药科技有限公司 | 2024-02-15 | — | — | WO | disclosed |
| CN-116640157-A | METTL3 inhibitor and composition thereof and application of METTL3 inhibitor and composition thereof in medicine | 海思科医药集团股份有限公司 | 2023-08-25 | — | — | CN | disclosed |
| WO-2023151697-A1 | METTL3 INHIBITOR AND COMPOSITION, AND APPLICATION OF SAME IN MEDICINE | 四川海思科制药有限公司 | 2023-08-17 | — | — | WO | disclosed |
| US-5330996-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1994-07-19 | — | — | US | disclosed |
| US-5227401-A | ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | disclosed |
| US-5223535-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| WO-1993009108-A1 | AMINO ACYL AMINO PROPARGYL DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | disclosed |
| WO-1993009086-A1 | PROPARGYL GLYCINE AMINO PROPARGYL DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | disclosed |
| WO-1993009087-A1 | ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | disclosed |
| EP-0539976-A1 | Ethynyl-alanine-amino-diol compounds for treatment of hypertension | G.D. Searle & Co. (US) | 1993-05-05 | — | — | EP | disclosed |