Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 5/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | S100B | P04271 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452089 | 0.86 | TSHR (0.54) | PKMTSHRGLAALDH1A1MAPT | |
| SCHEMBL29451379 | 0.83 | TSHR (0.58) | PKMTSHRGLAALDH1A1MAPT | |
| SCHEMBL30068292 | 0.79 | PKM (1.00) | PKMTSHRALDH1A1POLBL3MBTL1 | |
| SCHEMBL8777777 | 0.79 | PKM (1.00) | PKMTSHRALDH1A1POLBL3MBTL1 | |
| SCHEMBL8498272 | 0.78 | PKM (0.70) | PKMTSHRALDH1A1MAPTPOLB | |
| SCHEMBL7764285 | 0.78 | PKM (0.70) | PKMTSHRALDH1A1MAPTPOLB | |
| SCHEMBL4650366 | 0.78 | PKM (0.70) | PKMTSHRALDH1A1MAPTPOLB | |
| SCHEMBL4639549 | 0.77 | TSHR (0.51) | PKMTSHRGLAALDH1A1MAPT | |
| SCHEMBL1786119 | 0.77 | TSHR (0.51) | PKMTSHRGLAALDH1A1MAPT | |
| SCHEMBL4610100 | 0.75 | PKM (0.66) | PKMALDH1A1MAPTPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214295-B1 | HYDROXYACETAMIDOBENZENESULPHONAMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| US-6552225-B1 | Such as n-(2,3-dichloro-4-(methylaminosulphonyl)phenyl)-3,3,3-trifluoro-2-hydroxy-2 -methylpropanamide; diabetes, obesity, lactic acidaemia | ASTRAZENECA AB (SE) | 2003-04-22 | — | — | US | disclosed |
| EP-1214295-A2 | HYDROXYACETAMIDOBENZENESULPHONAMIDE DERIVATIVES | AstraZeneca AB (SE) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017955-A2 | HYDROXYACETAMIDOBENZENESULPHONAMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-15 | — | — | WO | disclosed |