Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.49 |
| ▸ | HTR2B | P41595 | 7/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5711093 | 1.00 | HTR2C (0.49) | HTR2CHTR2BHTR2ASMN1; SMN2NPC1 | |
| SCHEMBL6285192 | 0.83 | SMN1; SMN2 (0.54) | HTR2CHTR2BHTR2ASMN1; SMN2NPC1 | |
| SCHEMBL5720536 | 0.83 | SMN1; SMN2 (0.54) | HTR2CHTR2BHTR2ASMN1; SMN2NPC1 | |
| SCHEMBL7539295 | 0.72 | HTR2C (0.57) | HTR2CHTR2BHTR2ASMN1; SMN2NPC1 | |
| SCHEMBL29417058 | 0.71 | ALDH1A1 (0.68) | HTR2CHTR2BHTR2ASMN1; SMN2NPC1 | |
| SCHEMBL13052590 | 0.71 | ALDH1A1 (0.68) | HTR2CHTR2BHTR2ASMN1; SMN2NPC1 | |
| SCHEMBL30716906 | 0.70 | SYK (0.54) | HTR2CHTR2BHTR2ASMN1; SMN2KDM4E | |
| SCHEMBL13661860 | 0.70 | SYK (0.54) | HTR2CHTR2BSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4235232 | 0.70 | SYK (0.54) | HTR2CHTR2BHTR2ASMN1; SMN2KDM4E | |
| SCHEMBL11354880 | 0.70 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1291343-B1 | HYDROXYFORMAMIDINE DERIVATIVES AND MEDICINES CONTAINING THE SAME | TAISHO PHARMACEUTICAL CO LTD (JP) | 2006-12-06 | — | — | EP | disclosed |
| US-6670382-B2 | For inhibiting a synthase of 20-hydroxyeicosatetraenoic acid biosynthesized from arachidonic acid involved in constriction or dilation of microvessels in the kidneys and the cerebral blood vessels, or participates in cell proliferation | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2003-12-30 | — | — | US | disclosed |
| US-20030186979-A1 | Hydroxyformamidine derivatives and medicines containing the same | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2003-10-02 | — | — | US | disclosed |
| EP-1291343-A1 | HYDROXYFORMAMIDINE DERIVATIVES AND MEDICINES CONTAINING THE SAME | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186979-A1 | Hydroxyformamidine derivatives and medicines containing the same | HTR3E, PGF, VEGFA | HTR2C 23/4885HTR2B 67/4885HTR2A 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.