Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | EBP | Q15125 | 1/20 | 0.51 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17293683 | 0.87 | TSHR (0.46) | CXCR2ALDH1A1KDM4ECYP2C19L3MBTL1 | |
| SCHEMBL13205457 | 0.85 | ALDH1A1 (0.45) | CXCR2ALDH1A1KDM4EL3MBTL1ATM | |
| SCHEMBL9977970 | 0.84 | LMNA (0.51) | CXCR2ALDH1A1CCR1NPC1MEN1 | |
| SCHEMBL17293491 | 0.84 | LRRK2 (0.44) | CXCR2ALDH1A1KDM4EGAALRRK2 | |
| SCHEMBL17293655 | 0.84 | LRRK2 (0.44) | CXCR2ALDH1A1KDM4EGAALRRK2 | |
| SCHEMBL17293489 | 0.84 | LRRK2 (0.44) | CXCR2ALDH1A1KDM4EGAALRRK2 | |
| SCHEMBL2768040 | 0.83 | ATM (0.43) | CXCR2ALDH1A1GAACCR1NPC1 | |
| SCHEMBL17293877 | 0.83 | ATM (0.43) | CXCR2ALDH1A1KDM4EGAACYP2D6 | |
| SCHEMBL6562315 | 0.82 | CXCR2 (0.45) | CXCR2ALDH1A1KDM4EL3MBTL1ATM | |
| SCHEMBL19065947 | 0.81 | CXCR2 (0.44) | CXCR2ALDH1A1LRRK2MEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351933-B1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2006-11-22 | — | — | EP | disclosed |
| US-20060084641-A1 | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2006-04-20 | — | — | US | disclosed |
| US-20040048897-A1 | Il-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2004-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048897-A1 | Il-8 receptor antagonists | CXCL8, CCR8, TLR8 | CXCR2 11/4885ALDH1A1 2319/4885KDM4E 4263/4885 |
| US-20060084641-A1 | IL-8 receptor antagonists | CXCL8, CCR8, TLR8 | CXCR2 11/4885ALDH1A1 2319/4885KDM4E 4263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.