Histidine

Histidine

SCHEMBL5712337

NC(=O)CCC(N)C(=O)O.NC(Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BLM P54132 3/20 0.53
PMP22 Q01453 3/20 0.53
KMT2A Q03164 3/20 0.53
ALOX15 P16050 2/20 0.53
SLC7A5 Q01650 3/20 0.39
CYP3A4 P08684 2/20 0.39
GRIA2 P42262 3/20 0.39
CYP1A2 P05177 2/20 0.39
GRIA1 P42261 2/20 0.39
GRIA3 P42263 2/20 0.39
GRIA4 P48058 2/20 0.39
GRM8 O00222 1/20 0.39
GRM6 O15303 1/20 0.39
GRIN2D O15399 1/20 0.39
GRIN3B O60391 1/20 0.39
GSR P00390 1/20 0.39
GRIK1 P39086 1/20 0.39
GRM5 P41594 1/20 0.39
SLC1A3 P43003 1/20 0.39
SLC1A2 P43004 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL29755 1.00 BLM (0.53) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL9389369 0.96 ALOX15 (0.49) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL2730156 0.96 ALOX15 (0.49) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL2727906 0.96 ALOX15 (0.49) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL6534153 0.95 BLM (0.47) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL28193511 0.95 BLM (0.47) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL20680473 0.95 BLM (0.47) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL27730526 0.95 BLM (0.47) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL17628714 0.95 BLM (0.47) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL27615311 0.94 BLM (0.46) BLMPMP22KMT2AALOX15SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0594540-B1 Antiretroviral acyl compounds CIBA GEIGY AG (CH) 1998-04-01 EP claimed
WO-1992012952-A1 MALIC ACID DERIVATIVES AND COMPOSITIONS FOR THE TREATMENT OF PSORIASIS DEXTER CHEMICAL CORPORATION (US) 1992-08-06 WO claimed
US-20230257427-A1 INSECTICIDAL PEPTIDE PRODUCTION, PEPTIDE EXPRESSION IN PLANTS AND COMBINATIONS OF CYSTEINE RICH PEPTIDES Vestaron Corporation (US) 2023-08-17 US disclosed
US-11692016-B2 High gene expression yeast strain SUTERRA LLC 2023-07-04 US disclosed
CN-108136208-B Cannabinoid glycoside prodrugs and methods of synthesis 统帅青凤蝶生物科学公司 2022-07-15 CN disclosed
CN-107050462-B Solution-particle phase transition type anti-tumor drug delivery system and preparation method thereof 中山大学 2021-03-30 CN disclosed
EP-3766978-A1 TOXIC PEPTIDE PRODUCTION, PEPTIDE EXPRESSION IN PLANTS AND COMBINATIONS OF CYSTEINE RICH PEPTIDES Vestaron Corporation (US) 2021-01-20 EP disclosed
US-20200277345-A1 Insecticidal Peptide Production, Peptide Expression in Plants and Combinations of Cysteine Rich Peptides Vestaron Corporation (US) 2020-09-03 US disclosed
US-20200255482-A1 INSECTICIDAL COMBINATIONS Vestaron Corporation (US) 2020-08-13 US disclosed
US-20200207818-A1 HIGH GENE EXPRESSION YEAST STRAIN Vestaron Corporation (US) 2020-07-02 US disclosed
US-10669319-B2 Toxic peptide production, peptide expression in plants and combinations of cysteine rich peptides Vestaron Corporation (US) 2020-06-02 US disclosed
CN-1217927-C Novel 1, 2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism AVENTIS PHARMA GMBH (DE) 2005-09-07 CN disclosed
CN-1662493-A Ring-substituted diphenyl 2-azetidinones, method for the production thereof, medicaments containing said compounds and the use thereof AVENTIS PHARMA GMBH (DE) 2005-08-31 CN disclosed
CN-1618801-A D-aminoacylase mutants DAICEL CHEM (JP) 2005-05-25 CN disclosed
CN-1173951-C Substituted 1,3-diaryl-2-pyridine-2-yl-3-(pyridine-2-ylamino)-propanol derivatives, methods for their production, pharmaceutical compositions containing the same and their use ���ĵ�˹ҩ��¹����޹�˾ 2004-11-03 CN disclosed
US-6753177-B1 USED IN DRUG SCREENING FOR INHIBITORS OF DOG P-GLYCOPROTEIN (PGP) BECTON DICKINSON AND COMPANY 2004-06-22 US disclosed
CN-1498223-A Anti-angiogenic polypeptides M 2004-05-19 CN disclosed
CN-1483021-A Novel 1, 2-diphenyl azetidinones, process for their preparation, medicaments containing them and their use in the treatment of disorders of lipid metabolism ���ĵ�˹ҩ��¹����޹�˾ 2004-03-17 CN disclosed
EP-1220911-A2 P-GLYCOPROTEINS AND USES THEREOF GENTEST CORPORATION (US) 2002-07-10 EP disclosed
WO-2001023540-A2 P-GLYCOPROTEINS AND USES THEREOF GENTEST CORPORATION (US) 2001-04-05 WO disclosed