Histidine

Histidine

SCHEMBL6534153

NC(=O)CC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BLM P54132 3/20 0.47
PMP22 Q01453 3/20 0.47
KMT2A Q03164 3/20 0.47
ALOX15 P16050 2/20 0.47
SLC7A5 Q01650 3/20 0.36
CYP3A4 P08684 2/20 0.36
CYP1A2 P05177 2/20 0.35
GRIA2 P42262 3/20 0.35
GRIA1 P42261 2/20 0.35
GRIA3 P42263 2/20 0.35
GRIA4 P48058 2/20 0.35
GRM8 O00222 1/20 0.35
GRM6 O15303 1/20 0.35
GRIN2D O15399 1/20 0.35
GRIN3B O60391 1/20 0.35
GSR P00390 1/20 0.35
GRIK1 P39086 1/20 0.35
GRM5 P41594 1/20 0.35
SLC1A3 P43003 1/20 0.35
SLC1A2 P43004 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL17628714 1.00 BLM (0.47) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL29755 0.95 BLM (0.53) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL5712337 0.95 BLM (0.53) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL27703708 0.94 ALOX15 (0.42) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL9751058 0.93 ALOX15 (0.41) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL25284049 0.92 GSR (0.43) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL27980643 0.92 ALOX15 (0.40) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL1673654 0.92 SLC7A5 (0.41) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL17113605 0.92 SLC7A5 (0.41) BLMPMP22KMT2AALOX15SLC7A5
Histidine SCHEMBL28064125 0.92 SLC7A5 (0.41) BLMPMP22KMT2AALOX15SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210177948-A1 Antimalarial Enzyme Conjugates, Kits Containing Same, and Methods of Producing and Using Same THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA 2021-06-17 US disclosed
US-10767155-B2 Method of preparing a strain of Saccharomyces cerevisiae and a method of fermentation to produce ethanol SCANDINAVIAN TECHNOLOGY GROUP AB (SE) 2020-09-08 US disclosed
WO-2020032951-A1 ANTIMALARIAL ENZYME CONJUGATES, KITS CONTAINING SAME, AND METHODS OF PRODUCING AND USING SAME THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2020-02-13 WO disclosed
US-10385309-B2 Saccharomyces cerevisiae strains SCANDINAVIAN TECHNOLOGY GROUP AB (SE) 2019-08-20 US disclosed
US-9987241-B2 Enzyme conjugate and prodrug cancer therapy THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2018-06-05 US disclosed
EP-3134523-A1 SACCHAROMYCES CEREVISIAE STRAINS Scandinavian Technology Group AB (SE) 2017-03-01 EP disclosed
US-20170037361-A1 SACCHAROMYCES CEREVISIAE STRAINS SCANDINAVIAN TECHNOLOGY GROUP AB (SE) 2017-02-09 US disclosed
US-20160089350-A1 Enzyme Conjugate and Prodrug Cancer Therapy THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA 2016-03-31 US disclosed
WO-2015163814-A1 SACCHAROMYCES CEREVISIAE STRAINS SCANDINAVIAN TECHNOLOGY GROUP AB (SE) 2015-10-29 WO disclosed
US-20040185537-A1 Novel fructosyltransferases NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2004-09-23 US disclosed