Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 6/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.46 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5712390 | 1.00 | PRSS1 (0.46) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6418566 | 1.00 | PRSS1 (0.46) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL5516545 | 0.98 | ALDH1A1 (0.44) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11935021 | 0.91 | KAT2B (0.43) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11177848 | 0.91 | ALDH1A1 (0.49) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL23961158 | 0.91 | ALDH1A1 (0.49) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11476246 | 0.91 | MGLL (0.52) | LOXL2GAAABCG2MGLLCYP2A6 | |
| SCHEMBL11475163 | 0.91 | MGLL (0.52) | LOXL2GAAABCG2MGLLCYP2A6 | |
| SCHEMBL5283982 | 0.91 | MGLL (0.52) | LOXL2GAAABCG2MGLLCYP2A6 | |
| SCHEMBL11465958 | 0.91 | MGLL (0.52) | LOXL2GAAABCG2MGLLCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1715857-A1 | AMIDINE DERIVATIVES FOR TREATING AMYLOIDOSIS | Neurochem (International) Limited (CH) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005079780-A1 | AMIDINE DERIVATIVES FOR TREATING AMYLOIDOSIS | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2005-09-01 | — | — | WO | disclosed |