Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6809743 | 0.84 | KMT2A (0.55) | MEN1KMT2AALDH1A1KDM4ERAB9A | |
| SCHEMBL6812711 | 0.79 | PNLIP (0.49) | MEN1KMT2AALDH1A1HTTRAB9A | |
| SCHEMBL3042826 | 0.78 | ALDH1A1 (0.51) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL6813197 | 0.75 | ALDH1A1 (0.64) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL5713610 | 0.74 | ALDH1A1 (0.62) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL6813253 | 0.74 | MEN1 (0.63) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL6813678 | 0.74 | MEN1 (0.60) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL11806868 | 0.73 | ALDH1A1 (0.57) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL11438782 | 0.73 | ALDH1A1 (0.57) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL11501878 | 0.72 | MEN1 (0.64) | MEN1KMT2AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583752-B1 | CYCLIZATION PROCESS FOR SUBSTITUTED BENZOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-08-16 | — | — | EP | disclosed |
| US-7087761-B2 | Cyclization process for substituted benzothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1583752-A2 | CYCLIZATION PROCESS FOR SUBSTITUTED BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004060879-A2 | CYCLIZATION PROCESS FOR SUBSTITUTED BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | disclosed |
| US-20040138465-A1 | Cyclization process for substituted benzothiazole derivatives | HOFFMANN-LA ROCHE INC. | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138465-A1 | Cyclization process for substituted benzothiazole derivatives | CBR3, CBR1, OXTR | MEN1 4578/4885KMT2A 2298/4885MAPT 4736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.