Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.49 |
| ▸ | TUBB | P07437 | 6/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.49 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5716682 | 0.81 | MEN1 (0.50) | MEN1KMT2ARIPK1HRH4HRH3 | |
| SCHEMBL5716771 | 0.80 | MEN1 (0.57) | MEN1KMT2AMAPTRIPK1SMN1; SMN2 | |
| SCHEMBL5716713 | 0.80 | PDGFRB (0.48) | MEN1KMT2APDGFRBPDGFRATUBB4A | |
| SCHEMBL426783 | 0.79 | PDGFRB (0.74) | MEN1KMT2APDGFRBPDGFRATUBB4A | |
| SCHEMBL5716760 | 0.78 | DRD2 (0.50) | MEN1KMT2APOLBMAPTPDGFRB | |
| SCHEMBL4271585 | 0.77 | HRH4 (0.57) | RIPK1HRH4HRH3 | |
| SCHEMBL31088687 | 0.77 | HRH4 (0.57) | RIPK1HRH4HRH3 | |
| Hydrochloric Acid SCHEMBL1879831 | 0.76 | HRH4 (0.56) | RIPK1HRH4HRH3 | |
| SCHEMBL12606356 | 0.75 | RIPK1 (0.70) | RIPK1 | |
| SCHEMBL1336724 | 0.74 | MEN1 (0.65) | MEN1KMT2AHPGDPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276720-B1 | 2-ACYL INDOL DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | BAXTER HEALTHCARE SA (CH) | 2006-12-20 | — | — | EP | disclosed |
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | BAXTER ONCOLOGY GMBH | 2003-08-21 | — | — | US | disclosed |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | BECKERS THOMAS (DE) | 2002-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | MEN1 1405/4885KMT2A 554/4885HPGD 2111/4885 |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | MEN1 1405/4885KMT2A 554/4885HPGD 2111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.