Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | BCAT1 | P54687 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5716660 | 0.84 | KDM4E (0.39) | KDM4EFLT3AHRALDH1A1NPSR1 | |
| SCHEMBL5716792 | 0.82 | PDGFRB (0.42) | KDM4EPDGFRBPDGFRAFLT3ALDH1A1 | |
| SCHEMBL5716775 | 0.81 | KDM4E (0.39) | KDM4EPDGFRBPDGFRAFLT3AHR | |
| SCHEMBL6860275 | 0.77 | MEN1 (0.43) | KDM4EPDGFRBPDGFRAFLT3AHR | |
| SCHEMBL5716711 | 0.77 | AHR (0.48) | KDM4EPDGFRBPDGFRAAHRTSHR | |
| 2-Methoxybenzaldehyde SCHEMBL7152818 | 0.75 | PDGFRB (0.36) | KDM4EPDGFRBPDGFRAFLT3ALDH1A1 | |
| SCHEMBL6688305 | 0.75 | ALDH1A1 (0.42) | KDM4EPDGFRBPDGFRAFLT3ALDH1A1 | |
| SCHEMBL6870520 | 0.73 | FLT3 (0.37) | KDM4EFLT3AHRALDH1A1NPSR1 | |
| Nicotinaldehyde SCHEMBL7150684 | 0.70 | PADI4 (0.41) | AHRALDH1A1CNR1PADI4MEN1 | |
| SCHEMBL5692539 | 0.68 | HSD11B1 (0.43) | KDM4EAHRALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276720-B1 | 2-ACYL INDOL DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | BAXTER HEALTHCARE SA (CH) | 2006-12-20 | — | — | EP | disclosed |
| EP-1442015-A1 | USE OF 2-ACYLINDOLES IN THE TREATMENT OF TUMORS | Baxter Healthcare SA (CH) | 2004-08-04 | — | — | EP | disclosed |
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | BAXTER ONCOLOGY GMBH | 2003-08-21 | — | — | US | disclosed |
| WO-2003037861-A1 | USE OF 2-ACYLINDOLES IN THE TREATMENT OF TUMORS | BAXTER HEALTHCARE SA (CH) | 2003-05-08 | — | — | WO | disclosed |
| EP-1276720-A2 | 2-ACYL INDOL DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | ASTA Medica AG (DE) | 2003-01-22 | — | — | EP | disclosed |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | BECKERS THOMAS (DE) | 2002-07-11 | — | — | US | disclosed |
| WO-2001082909-A2 | 2-ACYL INDOL DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | BAXTER HEALTHCARE SA (DE) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | KDM4E 2155/4885PDGFRB 3807/4885PDGFRA 3147/4885 |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | KDM4E 2155/4885PDGFRB 3807/4885PDGFRA 3147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.