Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5716786 | 0.88 | ABL1 (0.51) | PDGFRBPDGFRAFLT3MEN1CYP1A2 | |
| SCHEMBL5716760 | 0.84 | DRD2 (0.50) | NPC1PDGFRBPDGFRARAB9AKDM4E | |
| SCHEMBL7066140 | 0.81 | PDGFRB (0.76) | PDGFRBPDGFRAFLT3MEN1CYP1A2 | |
| SCHEMBL5716713 | 0.79 | PDGFRB (0.48) | PDGFRBPDGFRAMEN1CYP1A2CYP3A4 | |
| SCHEMBL5716727 | 0.79 | MEN1 (0.57) | NPC1PDGFRBPDGFRARAB9ASMN1; SMN2 | |
| SCHEMBL5716694 | 0.79 | PDGFRB (0.53) | NPC1PDGFRBPDGFRAFLT3MEN1 | |
| SCHEMBL23170359 | 0.77 | ABL1 (0.54) | — | |
| SCHEMBL13180937 | 0.77 | ALDH1A1 (0.43) | PDGFRBPDGFRALMNAKDM4EMEN1 | |
| SCHEMBL15223892 | 0.77 | ABL1 (0.45) | PDGFRBPDGFRA | |
| SCHEMBL29722116 | 0.77 | ALDH1A1 (0.43) | PDGFRBPDGFRALMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276720-B1 | 2-ACYL INDOL DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | BAXTER HEALTHCARE SA (CH) | 2006-12-20 | — | — | EP | disclosed |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | BECKERS THOMAS (DE) | 2002-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | NPC1 3131/4885PDGFRB 3807/4885PDGFRA 3147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.