Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717158 | 1.00 | RAB9A (0.61) | RAB9AALDH1A1KMT2AMEN1CYP2C19 | |
| SCHEMBL5717126 | 0.89 | ALDH1A1 (0.59) | RAB9AALDH1A1KMT2AMEN1CYP2C19 | |
| SCHEMBL5717058 | 0.88 | HCRTR1 (0.50) | RAB9AALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL5717060 | 0.88 | HCRTR1 (0.50) | RAB9AALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL5244455 | 0.85 | TSHR (0.53) | ALDH1A1KMT2AMEN1TSHRHTT | |
| SCHEMBL5717134 | 0.84 | RAB9A (0.79) | RAB9AALDH1A1KMT2AMEN1CYP2C19 | |
| SCHEMBL5717136 | 0.84 | RAB9A (0.79) | RAB9AALDH1A1KMT2AMEN1CYP2C19 | |
| SCHEMBL1712952 | 0.84 | CYP2C19 (0.73) | RAB9AALDH1A1KMT2AMEN1CYP2C19 | |
| SCHEMBL5245725 | 0.84 | CYP2C19 (0.73) | RAB9AALDH1A1KMT2AMEN1CYP2C19 | |
| SCHEMBL5717002 | 0.80 | HCRTR1 (0.62) | ALDH1A1KMT2AMEN1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664010-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005068448-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-07-28 | — | — | WO | disclosed |