SCHEMBL571732

SCHEMBL571732

O=C1c2ccc(O)cc2OC(O)C1c1ccc(O)cc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 6/20 0.73
ESR1 P03372 5/20 0.73
CYP19A1 P11511 7/20 0.52
TUBB4A P04350 1/20 0.52
TUBB P07437 1/20 0.52
YES1 P07947 1/20 0.52
TUBA3C P0DPH7 1/20 0.52
TUBA1B P68363 1/20 0.52
TUBA4A P68366 1/20 0.52
TUBB4B P68371 1/20 0.52
TUBB3 Q13509 1/20 0.52
TUBB2A Q13885 1/20 0.52
TUBB8 Q3ZCM7 1/20 0.52
TUBA3E Q6PEY2 1/20 0.52
TUBA1A Q71U36 1/20 0.52
TUBA1C Q9BQE3 1/20 0.52
TUBB6 Q9BUF5 1/20 0.52
TUBB2B Q9BVA1 1/20 0.52
TUBB1 Q9H4B7 1/20 0.52
CTSV O60911 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30555701 1.00 ESR2 (0.73) ESR2ESR1CYP19A1TUBB4ATUBB
SCHEMBL2029052 1.00 ESR2 (0.73) ESR2ESR1CYP19A1TUBB4ATUBB
SCHEMBL4804016 0.88 ESR1 (0.58) ESR2ESR1CYP19A1MAOBPTPN1
SCHEMBL14124895 0.86 ESR2 (0.55) ESR2ESR1CYP19A1TUBB4ATUBB
SCHEMBL4725052 0.85 CYP19A1 (0.59) ESR2ESR1CYP19A1MAOB
SCHEMBL15100930 0.84 ESR1 (1.00) ESR2ESR1CYP19A1TUBB4ATUBB
SCHEMBL14045015 0.83 ESR1 (0.71) ESR2ESR1CYP19A1TUBB4ATUBB
SCHEMBL3445021 0.79 RECQL (0.56) ESR2ESR1CYP19A1PSMB5TTR
Garbanzol SCHEMBL29370332 0.78 ESR1 (0.73) ESR2ESR1CYP19A1TUBB4ATUBB
Garbanzol SCHEMBL9663852 0.78 ESR1 (0.73) ESR2ESR1CYP19A1TUBB4ATUBB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116660543-A Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof 中国人民解放军陆军军医大学第一附属医院 2023-08-29 CN claimed
US-7462478-B2 isolated from licorice; catalyzes a dehydration reaction of 2-hydroxy hisoflavanone NIHON UNIVERSITY (JP) 2008-12-09 US claimed
US-20070050865-A1 Polynucleotide encoding 2-hydorxyisoflavanone dehydratase and application of the same NIHON UNIVERSITY (JP) 2007-03-01 US claimed
US-20230255989-A1 GLYCAN COMPOSITIONS AND USES THEREOF DSM NUTRITIONAL PRODUCTS LLC (US) 2023-08-17 US disclosed
US-11229660-B2 Glycan therapeutics and method of treating conditions associated with TMAO KALEIDO BIOSCIENCES, INC. (US) 2022-01-25 US disclosed
US-20210137956-A1 GLYCAN COMPOSITIONS AND USES THEREOF HERCULES CAPITAL, INC. 2021-05-13 US disclosed
US-20210113596-A1 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF KALEIDO BIOSCIENCES, INC. (US) 2021-04-22 US disclosed
US-10881676-B2 Glycan therapeutics and related methods thereof KALEIDO BIOSCIENCES, INC. (US) 2021-01-05 US disclosed
US-10702542-B2 Glycan therapeutics and related methods thereof KALEIDO BIOSCIENCES, INC. (US) 2020-07-07 US disclosed
US-20200093845-A1 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF HERCULES CAPITAL, INC. 2020-03-26 US disclosed
US-20200093851-A1 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF HERCULES CAPITAL, INC. 2020-03-26 US disclosed
EP-1981980-A2 METHODS AND COMPOSITIONS FOR MODIFYING PLANT BIOSYNTHETIC PATHWAYS THE SAMUEL ROBERTS NOBLE FOUNDATION, INC. (US) 2008-10-22 EP disclosed
US-7384759-B2 Methods and compositions for determinig enzymatic activity and specificity of chalcone O-methyltransferases THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2008-06-10 US disclosed
WO-2008022265-A2 PLANT ISOFLAVONE AND ISOFLAVANONE O-METHYLTRANSFERASE GENES THE SAMUEL ROBERTS NOBLE FOUNDATION, INC. (US) 2008-02-21 WO disclosed
WO-2007092934-A2 METHODS AND COMPOSITIONS FOR MODIFYING PLANT BIOSYNTHETIC PATHWAYS THE SAMUEL ROBERTS NOBLE FOUNDATION, INC. (US) 2007-08-16 WO disclosed
US-20070050865-A1 Polynucleotide encoding 2-hydorxyisoflavanone dehydratase and application of the same NIHON UNIVERSITY (JP) 2007-03-01 US disclosed
US-7084265-B1 Polynucleotide encoding 2-hydroxyisoflavanone synthase NIHON UNIVERSITY (JP) 2006-08-01 US disclosed
US-20040111218-A1 Methods and compositions for determining enzymatic activity and specificity of methlytransferases SAMUEL ROBERTS NOBLE FOUNDATION, THE 2004-06-10 US disclosed
WO-2003006987-A9 METHODS AND COMPOSITIONS FOR DETERMINING ENZYMATIC ACTIVITY AND SPECIFICITY OF METHYLTRANSFERASES SALK INST FOR BIOLOGICAL STUDI (US) 2003-04-24 WO disclosed
WO-2003006987-A1 METHODS AND COMPOSITIONS FOR DETERMINING ENZYMATIC ACTIVITY AND SPECIFICITY OF METHYLTRANSFERASES THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2003-01-23 WO disclosed