Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | PDE4A | P27815 | 2/20 | 0.53 |
| ▸ | SNCA | P37840 | 2/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17029396 | 0.90 | MAPT (0.55) | MAPTPTGS1PDE4ASNCAPDE3A | |
| SCHEMBL12921592 | 0.90 | MAPT (0.55) | MAPTPTGS1PDE4ASNCAPDE3A | |
| SCHEMBL5821764 | 0.81 | CYP2D6 (0.47) | MAPTPTGS1PDE4ASNCAPDE3A | |
| SCHEMBL5819450 | 0.81 | CYP2D6 (0.47) | MAPTPTGS1PDE4ASNCAPDE3A | |
| SCHEMBL5819455 | 0.81 | CYP2D6 (0.47) | MAPTPTGS1PDE4ASNCAPDE3A | |
| SCHEMBL5821762 | 0.81 | CYP2D6 (0.47) | MAPTPTGS1PDE4ASNCAPDE3A | |
| SCHEMBL7915504 | 0.76 | MAPT (0.49) | MAPTPTGS1PDE4ASNCAPDE3A | |
| SCHEMBL7915508 | 0.76 | MAPT (0.49) | MAPTPTGS1PDE4ASNCAPDE3A | |
| SCHEMBL5820368 | 0.75 | MAPT (0.58) | MAPTPTGS1PDE4ASNCAPDE3A | |
| SCHEMBL14894567 | 0.75 | MAPT (0.52) | MAPTPTGS1PDE4ASNCAPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140031432-A1 | TREATMENT OF MITOCHONDRIAL DISEASES WITH VITAMIN K | AMPERE LIFE SCIENCES, INC. (US) | 2014-01-30 | — | — | US | disclosed |
| EP-2601168-A1 | TREATMENT OF MITOCHONDRIAL DISEASES WITH VITAMIN K | Ampere Life Sciences, Inc. (US) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012019032-A1 | TREATMENT OF MITOCHONDRIAL DISEASES WITH VITAMIN K | AMPERE LIFE SCIENCES, INC. (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031432-A1 | TREATMENT OF MITOCHONDRIAL DISEASES WITH VITAMIN K | FH, COQ8A, BCKDK | MAPT 1790/4885PTGS1 2269/4885PDE4A 2847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.