Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 14/20 | 0.55 |
| ▸ | THRB | P10828 | 14/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5718090 | 0.93 | THRA (0.49) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4927337 | 0.90 | THRB (0.49) | THRATHRBSMN1; SMN2PPARAMEN1 | |
| SCHEMBL5717927 | 0.89 | THRA (0.45) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL5717807 | 0.89 | THRA (0.45) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL5722535 | 0.88 | THRA (0.45) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4931811 | 0.88 | THRA (0.40) | THRATHRBSMN1; SMN2PPARAMEN1 | |
| SCHEMBL4932877 | 0.87 | THRA (0.57) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4923097 | 0.85 | THRB (0.72) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL5717939 | 0.84 | THRB (0.41) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4922947 | 0.83 | THRB (0.41) | THRATHRBSMN1; SMN2PPARAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |