SCHEMBL5717875

O=C(O)C(F)Cc1cc(Cl)c(OCc2cc(NC3CCC3)cc(C(F)(F)F)c2)c(Cl)c1.O=C(O)CCc1cc(Cl)c(OCc2cc(Cl)cc(NC3CCC3)c2)c(Cl)c1.O=C(O)CCc1cc(Cl)c(OCc2cc(NC3CCC3)cc(C(F)(F)F)c2)c(Cl)c1.O=C(O)CNC(=O)c1cc(Cl)c(OCc2cc(Cl)cc(NCC3CC3)c2F)c(Cl)c1.O=C(O)Cc1cc(Br)c(OCc2cc(Cl)cc(NCC3CC3)c2F)c(Br)c1

nearest known ligand 0.33

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	THRA	P10827	1/20	0.33

▸	THRB	P10828	1/20	0.33

▸	CRHR1	P34998	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL5717844	0.88	THRA (0.36)	THRATHRB
SCHEMBL5718194	0.83	THRA (0.34)	THRATHRB
SCHEMBL5718744	0.82	THRA (0.38)	THRATHRBCRHR1
SCHEMBL5718115	0.82	THRA (0.38)	THRATHRB
SCHEMBL5717918	0.81	THRB (0.37)	THRATHRB
SCHEMBL5718189	0.80	THRA (0.46)	THRATHRBCRHR1
SCHEMBL5717943	0.79	THRA (0.42)	THRATHRBCRHR1
SCHEMBL5717710	0.79	THRA (0.32)	THRATHRB
SCHEMBL5717915	0.78	THRA (0.36)	THRATHRB
SCHEMBL5717896	0.78	THRA (0.37)	THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1732533-A1	THYROID RECEPTOR AGONISTS	KARO BIO AB (SE)	2006-12-20	—	—	EP	disclosed
WO-2005092317-A1	THYROID RECEPTOR AGONISTS	KARO BIO AB (SE)	2005-10-06	—	—	WO	disclosed