Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 15/20 | 0.38 |
| ▸ | THRB | P10828 | 15/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5718120 | 0.90 | THRA (0.31) | THRATHRB | |
| SCHEMBL4926378 | 0.83 | THRA (0.51) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL5718054 | 0.82 | MEN1 (0.38) | THRATHRB | |
| SCHEMBL5717875 | 0.82 | THRA (0.33) | THRATHRB | |
| SCHEMBL5717762 | 0.81 | THRA (0.34) | THRATHRBPTGES | |
| SCHEMBL5717844 | 0.81 | THRA (0.36) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4934402 | 0.81 | THRA (0.38) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL5718056 | 0.80 | THRA (0.36) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4931367 | 0.80 | THRA (0.51) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL5718046 | 0.79 | THRA (0.36) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |