Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464056 | 1.00 | OPRM1 (0.57) | OPRM1SIGMAR1CHRM2CHRM3CHRM4 | |
| SCHEMBL6312702 | 0.86 | CHRM4 (0.59) | OPRM1SIGMAR1CHRM2CHRM3CHRM4 | |
| SCHEMBL8283548 | 0.86 | CHRM4 (0.49) | OPRM1SIGMAR1CHRM2CHRM3CHRM4 | |
| SCHEMBL4463836 | 0.81 | OPRM1 (0.57) | OPRM1SIGMAR1CHRM2CHRM3CHRM4 | |
| SCHEMBL4463840 | 0.81 | OPRM1 (0.57) | OPRM1SIGMAR1CHRM2CHRM3CHRM4 | |
| SCHEMBL3817982 | 0.78 | OPRM1 (0.59) | OPRM1SIGMAR1CHRM2CHRM3CHRM4 | |
| SCHEMBL1220330 | 0.78 | OPRM1 (0.59) | OPRM1SIGMAR1CHRM2CHRM3CHRM4 | |
| SCHEMBL7013887 | 0.78 | SIGMAR1 (0.60) | OPRM1SIGMAR1CHRM2CHRM3CHRM4 | |
| SCHEMBL11577007 | 0.78 | OPRM1 (0.86) | OPRM1SIGMAR1CHRM2CHRM3MEN1 | |
| SCHEMBL4891859 | 0.78 | CHRM3 (0.57) | OPRM1SIGMAR1CHRM2CHRM3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718633-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | Neuromed Pharmaceuticals, Ltd. (CA) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005070919-A1 | N-TYPE CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2005-08-04 | — | — | WO | disclosed |