Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | PTPRF | P10586 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5718408 | 0.77 | MAPT (0.47) | MAPTALDH1A1GLASMN1; SMN2MEN1 | |
| SCHEMBL5718499 | 0.75 | MAPT (0.48) | MAPTALDH1A1GLASMN1; SMN2MEN1 | |
| SCHEMBL9003269 | 0.72 | MAPT (0.70) | MAPTALDH1A1GLASMN1; SMN2MEN1 | |
| SCHEMBL10489391 | 0.69 | MAPT (0.72) | MAPTALDH1A1GLASMN1; SMN2MEN1 | |
| SCHEMBL4951837 | 0.69 | ALDH1A1 (0.73) | MAPTALDH1A1GLASMN1; SMN2MEN1 | |
| SCHEMBL14117517 | 0.67 | ALDH1A1 (0.66) | MAPTALDH1A1GLASMN1; SMN2MEN1 | |
| SCHEMBL18549022 | 0.67 | ALDH1A1 (0.66) | MAPTALDH1A1GLASMN1; SMN2MEN1 | |
| SCHEMBL5153567 | 0.67 | MAPT (0.63) | MAPTALDH1A1GLASMN1; SMN2MEN1 | |
| SCHEMBL6645341 | 0.67 | MAPT (0.54) | MAPTALDH1A1GLASMN1; SMN2MEN1 | |
| SCHEMBL9651956 | 0.67 | MAPT (0.68) | MAPTALDH1A1GLASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1018333-B1 | Use of cationic monobenzene nitroanilines for dyeing keratin fibres , compositions and dyeing process | OREAL (FR) | 2006-03-01 | — | — | EP | claimed |
| US-6478827-B1 | Use of cationic monobenzene nitroanilines in the dyeing of keratinous fibers, dyeing compositions and dyeing processes | L'ORéAL S.A. (FR) | 2002-11-12 | — | — | US | claimed |
| US-6478827-B1 | Use of cationic monobenzene nitroanilines in the dyeing of keratinous fibers, dyeing compositions and dyeing processes | L'ORéAL S.A. (FR) | 2002-11-12 | — | — | US | disclosed |