Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.67 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.67 |
| ▸ | TACR1 | P25103 | 2/20 | 0.61 |
| ▸ | CTSL | P07711 | 1/20 | 0.60 |
| ▸ | CTSB | P07858 | 1/20 | 0.60 |
| ▸ | CTSS | P25774 | 1/20 | 0.60 |
| ▸ | CTSK | P43235 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.57 |
| ▸ | MME | P08473 | 1/20 | 0.57 |
| ▸ | ECE1 | P42892 | 1/20 | 0.57 |
| ▸ | TYR | P14679 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL7316336 | 0.94 | ITGB3 (0.61) | ITGB3ITGA2BTACR1CTSLCTSB | |
| Glycine SCHEMBL7320734 | 0.94 | ITGB3 (0.61) | ITGB3ITGA2BTACR1CTSLCTSB | |
| SCHEMBL479010 | 0.93 | TACR1 (0.68) | ITGB3ITGA2BTACR1CTSLCTSB | |
| SCHEMBL26661077 | 0.93 | TACR1 (0.68) | ITGB3ITGA2BTACR1CTSLCTSB | |
| SCHEMBL220648 | 0.93 | TACR1 (0.68) | ITGB3ITGA2BTACR1CTSLCTSB | |
| SCHEMBL219151 | 0.93 | TACR1 (0.68) | ITGB3ITGA2BTACR1CTSLCTSB | |
| SCHEMBL7372270 | 0.93 | TACR1 (0.68) | ITGB3ITGA2BTACR1CTSLCTSB | |
| Hypochlorous Acid SCHEMBL7368156 | 0.90 | TACR1 (0.65) | ITGB3ITGA2BTACR1CTSLCTSB | |
| SCHEMBL4652252 | 0.90 | ITGB3 (0.62) | ITGB3ITGA2BTACR1CTSLCTSB | |
| D-Phenylalanine SCHEMBL9445679 | 0.88 | ITGB3 (0.63) | ITGB3ITGA2BTACR1CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817795-B1 | NOVEL 4-SUBSTITUTED-3-PEPTIDYL-AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE INHIBITOR | NAEJA PHARMACEUTICAL INC (CA) | 2000-11-15 | — | — | EP | claimed |
| EP-0817795-A1 | NOVEL 4-SUBSTITUTED-3-PEPTIDYL-AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE INHIBITOR | SYNPHAR LABORATORIES INC. (CA) | 1998-01-14 | — | — | EP | claimed |
| WO-1996032408-A1 | NOVEL 4-SUBSTITUTED-3-PEPTIDYL-AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE INHIBITOR | SYNPHAR LABORATORIES, INC. (US) | 1996-10-17 | — | — | WO | claimed |
| EP-1408986-A4 | PROTEOMIMETIC COMPOUNDS AND METHODS | UNIV YALE (US) | 2006-01-11 | — | — | EP | disclosed |
| EP-1408986-A2 | PROTEOMIMETIC COMPOUNDS AND METHODS | YALE UNIVERSITY (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2002089738-A2 | PROTEOMIMETIC COMPOUNDS AND METHODS | YALE UNIVERSITY (US) | 2002-11-14 | — | — | WO | disclosed |