SCHEMBL5721168

SCHEMBL5721168

CC(C)C1=Cc2c(ccc(-c3ccccc3)c2-c2cc([Si](C)(C)C)cc([Si](C)(C)C)c2)[CH]1

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
METAP2 P50579 1/20 0.30
ADORA3 P0DMS8 1/20 0.30
ADORA2A P29274 1/20 0.30
ADORA2B P29275 1/20 0.30
ADORA1 P30542 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5721546 0.88
SCHEMBL5721287 0.83 ESR2 (0.30)
SCHEMBL5721939 0.83 METAP2 (0.37) METAP2
SCHEMBL5721371 0.82 ADORA3 (0.32) ADORA3ADORA2AADORA2BADORA1
SCHEMBL5721767 0.82
SCHEMBL5721459 0.82
SCHEMBL5721232 0.80 RXRA (0.33)
SCHEMBL5721450 0.80 TACR1 (0.36) METAP2
SCHEMBL5721616 0.80
SCHEMBL5721183 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1640377-A1 Metallocenes and catalyst compositions derived therefrom Exxonmobil Chemical Patents Inc. (US) 2006-03-29 EP disclosed