Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 16/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9572108 | 0.89 | EPHX2 (0.57) | EPHX2FAAH | |
| SCHEMBL9640923 | 0.89 | HRH1 (0.43) | EPHX2MCHR1 | |
| SCHEMBL9572112 | 0.89 | EPHX2 (0.57) | EPHX2FAAH | |
| SCHEMBL30045 | 0.89 | EPHX2 (0.57) | EPHX2FAAH | |
| SCHEMBL12807880 | 0.82 | FPR2 (0.40) | EPHX2FPR2PROKR1MCHR1 | |
| SCHEMBL12056318 | 0.82 | MCHR1 (0.44) | TSHRMCHR1 | |
| SCHEMBL20196968 | 0.82 | FPR2 (0.40) | EPHX2FPR2PROKR1MCHR1 | |
| SCHEMBL16242402 | 0.81 | EPHX2 (0.58) | EPHX2FAAHTSHR | |
| SCHEMBL17123795 | 0.81 | EPHX2 (0.54) | EPHX2FAAHTSHR | |
| SCHEMBL5722064 | 0.80 | EPHX2 (0.50) | EPHX2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186724-B2 | Heterocyclic substituted carbonyl derivatives and their use as dopamine D3 receptor ligands | AVENTIS PHARMACEUTICALS INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186724-B2 | Heterocyclic substituted carbonyl derivatives and their use as dopamine D3 receptor ligands | AVENTIS PHARMACEUTICALS INC. (US) | 2007-03-06 | — | — | US | disclosed |
| EP-1716100-A2 | THERAPEUTIC AMIDE DERIVATIVES | Pfizer, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080317-A2 | THERAPEUTIC AMIDE DERIVATIVES | PFIZER JAPAN, INC. (JP) | 2005-09-01 | — | — | WO | disclosed |