Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
| ▸ | PTGES | O14684 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | AURKAIP1 | Q9NWT8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11184672 | 0.88 | CCR5 (0.56) | KMT2AALDH1A1KDM4EMEN1APOBEC3G | |
| SCHEMBL5722107 | 0.84 | CCR5 (0.53) | KMT2AALDH1A1APOBEC3GCCR5TDP1 | |
| SCHEMBL21565813 | 0.83 | ALDH1A1 (0.53) | KMT2AALDH1A1RXFP1KDM4EMEN1 | |
| SCHEMBL7200356 | 0.83 | KMT2A (0.55) | KMT2AALDH1A1RXFP1KDM4EMEN1 | |
| SCHEMBL9289307 | 0.82 | TDP1 (0.59) | KMT2AALDH1A1KDM4EMEN1APOBEC3G | |
| SCHEMBL16222119 | 0.82 | CCR5 (0.51) | KMT2AALDH1A1KDM4EMEN1APOBEC3G | |
| SCHEMBL11576737 | 0.81 | CA12 (0.59) | KMT2AALDH1A1RXFP1KDM4EMEN1 | |
| SCHEMBL2414975 | 0.81 | SIGMAR1 (0.57) | KMT2AALDH1A1RXFP1KDM4EMEN1 | |
| SCHEMBL19264967 | 0.81 | SIGMAR1 (0.57) | KMT2AALDH1A1RXFP1KDM4EMEN1 | |
| SCHEMBL1850325 | 0.81 | APOBEC3G (0.50) | KMT2AALDH1A1KDM4EMEN1APOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673369-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2006-06-28 | — | — | EP | claimed |
| WO-2005030761-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | claimed |
| CN-102245596-A | Quinazolinamide derivatives | MERCK PATENT GMBH | 2011-11-16 | — | — | CN | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2009133127-A1 | FUSED BICYCLIC COMPOUNDS AND USE THEREOF AS PI3K INHIBITORS | MERCK SERONO S.A. (CH) | 2009-11-05 | — | — | WO | disclosed |
| US-4113463-A | BENZENESULFONAMIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1978-09-12 | — | — | US | disclosed |
| US-4070176-A | WITH A BENZENESULFONAMIDE | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1978-01-24 | — | — | US | disclosed |