Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.39 |
| ▸ | THRB | P10828 | 8/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5109436 | 0.96 | THRB (0.42) | THRATHRBDHODHACP1KMT2A | |
| SCHEMBL5117180 | 0.94 | ALDH1A1 (0.41) | THRATHRBALDH1A1LMNAMAPT | |
| SCHEMBL5722509 | 0.91 | ALDH1A1 (0.36) | THRATHRBDHODHALDH1A1ACP1 | |
| SCHEMBL5117744 | 0.87 | THRB (0.41) | THRATHRBDHODHALDH1A1ACP1 | |
| SCHEMBL5723101 | 0.87 | THRA (0.40) | THRATHRBALDH1A1ACP1KDM4E | |
| SCHEMBL5109706 | 0.85 | THRA (0.41) | THRATHRBDHODHALDH1A1ACP1 | |
| SCHEMBL5119963 | 0.85 | GRIN1 (0.41) | THRATHRBKMT2APOLBNPC1 | |
| SCHEMBL5110513 | 0.85 | ALDH1A1 (0.40) | THRATHRBALDH1A1ACP1KDM4E | |
| SCHEMBL5118488 | 0.84 | ALDH1A1 (0.43) | THRATHRBALDH1A1LMNAMAPT | |
| SCHEMBL5107398 | 0.83 | THRB (0.45) | THRATHRBDHODHACP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |