Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5722505 | 0.91 | THRB (0.42) | SMN1; SMN2ALDH1A1MAPK1HTTTHRB | |
| SCHEMBL5722840 | 0.88 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1MAPK1HTTTHRB | |
| SCHEMBL5722486 | 0.87 | THRA (0.36) | SMN1; SMN2ALDH1A1MAPK1HTTTHRB | |
| SCHEMBL5722648 | 0.84 | THRB (0.42) | THRBTHRA | |
| SCHEMBL5118797 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1MAPK1HTTTHRB | |
| SCHEMBL5104287 | 0.84 | THRA (0.37) | SMN1; SMN2ALDH1A1MAPK1HTTTHRB | |
| SCHEMBL5722588 | 0.80 | ALDH1A1 (0.35) | SMN1; SMN2ALDH1A1MAPK1HTTTHRB | |
| SCHEMBL5117297 | 0.80 | THRB (0.50) | SMN1; SMN2ALDH1A1THRBTHRAMEN1 | |
| SCHEMBL5112377 | 0.80 | THRB (0.50) | THRBTHRA | |
| SCHEMBL5722489 | 0.79 | KMT2A (0.35) | SMN1; SMN2ALDH1A1POLBLMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |