Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.42 |
| ▸ | THRA | P10827 | 18/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723368 | 0.91 | THRA (0.43) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5717929 | 0.90 | THRB (0.44) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5722612 | 0.89 | THRB (0.48) | THRBTHRAMEN1ALDH1A1ABL1 | |
| SCHEMBL5717870 | 0.89 | THRB (0.42) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5723147 | 0.89 | THRA (0.40) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5722466 | 0.88 | THRA (0.45) | THRBTHRAMEN1ALDH1A1ABL1 | |
| SCHEMBL5722485 | 0.87 | THRA (0.42) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5722581 | 0.86 | THRA (0.42) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5722682 | 0.85 | THRB (0.49) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5722648 | 0.85 | THRB (0.42) | THRBTHRAESR1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |