Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 17/20 | 0.49 |
| ▸ | THRA | P10827 | 16/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104139 | 0.89 | THRA (0.61) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5112680 | 0.89 | THRA (0.47) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5717988 | 0.89 | THRB (0.52) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5717733 | 0.88 | THRB (0.48) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5108749 | 0.88 | THRA (0.62) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5103539 | 0.87 | THRA (0.49) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5106856 | 0.87 | THRB (0.48) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5108841 | 0.87 | FABP4 (0.42) | THRBTHRA | |
| SCHEMBL5722485 | 0.87 | THRA (0.42) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL5103564 | 0.86 | THRB (0.49) | THRBTHRAESR1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |