Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.38 |
| ▸ | THRA | P10827 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5722626 | 0.92 | THRA (0.37) | THRBTHRAALDH1A1SCN9AKMT2A | |
| SCHEMBL5717860 | 0.92 | KMT2A (0.33) | THRBTHRAALDH1A1MDM2MAPK1 | |
| SCHEMBL5722588 | 0.91 | ALDH1A1 (0.35) | THRBALDH1A1MAPK1HTTKMT2A | |
| SCHEMBL5722840 | 0.91 | ALDH1A1 (0.38) | THRBTHRAALDH1A1MAPK1HTT | |
| SCHEMBL5722767 | 0.89 | THRA (0.47) | THRBTHRAALDH1A1MDM2MAPK1 | |
| SCHEMBL5717864 | 0.88 | KMT2A (0.33) | ALDH1A1MAPK1HTTKMT2APKM | |
| SCHEMBL5111554 | 0.87 | THRA (0.38) | THRBTHRAALDH1A1MDM2MAPK1 | |
| SCHEMBL5718237 | 0.86 | HSD17B10 (0.33) | THRBALDH1A1MAPK1HTTKMT2A | |
| SCHEMBL5718154 | 0.84 | TAOK1 (0.33) | ALDH1A1MAPK1HTTKMT2APKM | |
| SCHEMBL5722493 | 0.84 | SENP5 (0.35) | THRBTHRAALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |