Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.57 |
| ▸ | ACE | P12821 | 2/20 | 0.57 |
| ▸ | ECE1 | P42892 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5722993 | 1.00 | MME (0.57) | MMEACEECE1GAAKDM4E | |
| SCHEMBL5723402 | 0.89 | ECE1 (0.61) | MMEACEECE1GAASMN1; SMN2 | |
| SCHEMBL5723632 | 0.89 | ECE1 (0.71) | MMEACEECE1GAASMN1; SMN2 | |
| SCHEMBL5723510 | 0.87 | MME (0.59) | MMEACEECE1GAASMN1; SMN2 | |
| SCHEMBL5722920 | 0.87 | ECE1 (0.58) | MMEACEECE1GAASMN1; SMN2 | |
| SCHEMBL5723075 | 0.86 | GAA (0.55) | MMEACEECE1GAAKDM4E | |
| SCHEMBL5723488 | 0.86 | ECE1 (0.66) | MMEACEECE1SMN1; SMN2LMNA | |
| SCHEMBL5723778 | 0.83 | MME (0.56) | MMEACEECE1KAT6A | |
| SCHEMBL5723097 | 0.83 | ECE1 (0.67) | MMEACEECE1SMN1; SMN2LMNA | |
| SCHEMBL5723245 | 0.82 | ECE1 (0.59) | MMEACEECE1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317428-B1 | PYRROLIDINE-2-CARBOXYLIC ACID HYDRAZIDE DERIVATIVES FOR USE AS METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2006-04-19 | — | — | EP | disclosed |