Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 3/20 | 0.61 |
| ▸ | MME | P08473 | 2/20 | 0.61 |
| ▸ | ACE | P12821 | 2/20 | 0.61 |
| ▸ | KAT6A | Q92794 | 11/20 | 0.44 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | KAT7 | O95251 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KAT6B | Q8WYB5 | 1/20 | 0.41 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723632 | 0.92 | ECE1 (0.71) | ECE1MMEACEKAT6AEIF2AK3 | |
| SCHEMBL5723510 | 0.91 | MME (0.59) | ECE1MMEACEKAT6ACYP3A4 | |
| SCHEMBL5722920 | 0.90 | ECE1 (0.58) | ECE1MMEACEKAT6AEIF2AK3 | |
| SCHEMBL5722992 | 0.89 | MME (0.57) | ECE1MMEACEKAT6AEIF2AK3 | |
| SCHEMBL5722993 | 0.89 | MME (0.57) | ECE1MMEACEKAT6AEIF2AK3 | |
| SCHEMBL5723778 | 0.86 | MME (0.56) | ECE1MMEACEKAT6AKAT7 | |
| SCHEMBL5723097 | 0.86 | ECE1 (0.67) | ECE1MMEACEEIF2AK3HCRTR1 | |
| SCHEMBL5723488 | 0.85 | ECE1 (0.66) | ECE1MMEACEEIF2AK3HCRTR1 | |
| SCHEMBL5723356 | 0.85 | ALDH1A1 (0.51) | ECE1MMEACEHCRTR1HCRTR2 | |
| SCHEMBL5723398 | 0.85 | ECE1 (0.56) | ECE1MMEACEKAT6AEIF2AK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317428-B1 | PYRROLIDINE-2-CARBOXYLIC ACID HYDRAZIDE DERIVATIVES FOR USE AS METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2006-04-19 | — | — | EP | disclosed |