Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 3/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 6/20 | 0.37 |
| ▸ | USP8 | P40818 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723859 | 0.96 | PIN1 (0.52) | PIN1CSNK1A1CLK4SRCUSP8 | |
| SCHEMBL5723448 | 0.81 | PIN1 (0.52) | PIN1CSNK1A1CLK4SRCAR | |
| SCHEMBL20101542 | 0.79 | PIN1 (0.51) | PIN1CSNK1A1CLK4GAAL3MBTL1 | |
| SCHEMBL5723588 | 0.79 | PIN1 (0.56) | PIN1CSNK1A1CLK4SRCSQOR | |
| SCHEMBL2527306 | 0.78 | PIN1 (0.59) | PIN1CSNK1A1CLK4GAAL3MBTL1 | |
| SCHEMBL5723434 | 0.77 | PIN1 (0.51) | PIN1CSNK1A1CLK4GAAL3MBTL1 | |
| SCHEMBL22895389 | 0.75 | TSHR (0.41) | PIN1USP8TSHRKCNJ5KCNJ3 | |
| SCHEMBL5723482 | 0.74 | PIN1 (0.51) | PIN1CSNK1A1CLK4GAAL3MBTL1 | |
| SCHEMBL5723463 | 0.73 | PIN1 (0.54) | PIN1CSNK1A1CLK4GAAL3MBTL1 | |
| SCHEMBL23835201 | 0.72 | SRC (0.38) | PIN1CSNK1A1CLK4SRCUSP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406876-B1 | 2-ANILINO-PYRIMIDINE DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-12-27 | — | — | EP | disclosed |