SCHEMBL5723919

SCHEMBL5723919

O=C(NCCNC(=O)c1csc(N2CC(O)C2)n1)OCc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
DPP8 Q6V1X1 1/20 0.47
DPP9 Q86TI2 1/20 0.47
TGM2 P21980 1/20 0.37
GAA P10253 2/20 0.37
RAB9A P51151 2/20 0.37
MAPT P10636 3/20 0.37
ALDH1A1 P00352 2/20 0.37
HPGD P15428 1/20 0.37
TDP1 Q9NUW8 1/20 0.36
PTPN1 P18031 1/20 0.35
CCR3 P51677 1/20 0.35
ATM Q13315 1/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
POLB P06746 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5723938 0.90 DPP8 (0.43) DPP8DPP9TGM2GAARAB9A
SCHEMBL5723581 0.88 DPP8 (0.43) DPP8DPP9TGM2GAARAB9A
SCHEMBL5724524 0.87 DPP8 (0.43) DPP8DPP9TGM2GAARAB9A
SCHEMBL5724479 0.85 DPP8 (0.45) DPP8DPP9TGM2RAB9AMAPT
SCHEMBL5723981 0.85 DPP8 (0.40) DPP8DPP9TGM2GAARAB9A
SCHEMBL5724165 0.85 RAB9A (0.49) DPP8DPP9GAARAB9AMAPT
SCHEMBL5724050 0.84 DPP8 (0.43) DPP8DPP9TGM2GAARAB9A
SCHEMBL5723847 0.84 DPP8 (0.38) DPP8DPP9GAARAB9AMAPT
SCHEMBL5724203 0.84 DPP8 (0.40) DPP8DPP9TGM2GAAMAPT
SCHEMBL5724199 0.82 DPP8 (0.42) DPP8DPP9TGM2GAARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1340757-B1 1-METHYLCARBAPENEM DERIVATIVES SANKYO CO (JP) 2006-10-11 EP disclosed
US-7001897-B2 1-methylcarbapenem derivatives SANKYO COMPANY, LIMITED (JP) 2006-02-21 US disclosed
US-20040014962-A1 1-Methylcarbapenem derivatives SANKYO COMPANY, LIMITED (JP) 2004-01-22 US disclosed
EP-1340757-A1 1-METHYLCARBAPENEM DERIVATIVES Sankyo Company, Limited (JP) 2003-09-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040014962-A1 1-Methylcarbapenem derivatives CD14, CPT1A, ACMSD DPP8 1397/4885DPP9 703/4885TGM2 2820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.