Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422638 | 1.00 | — | — | |
| SCHEMBL14864006 | 0.87 | GNAI3 (0.41) | ALDH1A1HTTNPSR1HTR1AHTR2A | |
| SCHEMBL21907248 | 0.87 | GNAI3 (0.41) | ALDH1A1HTTNPSR1HTR1AHTR2A | |
| SCHEMBL6497217 | 0.87 | ALDH1A1 (0.39) | ALDH1A1HTTNPSR1HTR1AHTR2A | |
| SCHEMBL31478000 | 0.87 | ALDH1A1 (0.39) | ALDH1A1HTTNPSR1HTR1AHTR2A | |
| SCHEMBL957418 | 0.87 | ALDH1A1 (0.39) | ALDH1A1HTTNPSR1HTR1AHTR2A | |
| SCHEMBL1363715 | 0.86 | — | — | |
| SCHEMBL788760 | 0.86 | — | — | |
| SCHEMBL302276 | 0.86 | — | — | |
| SCHEMBL3222967 | 0.85 | CYP1A2 (0.59) | ALDH1A1HTTNPSR1HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104069109-B | Application of substituted piperazine-1, 4-diamide compound in pharmacy | 中国医学科学院医药生物技术研究所 | 2017-01-25 | — | — | CN | claimed |
| CN-105902546-A | Application of substituted piperazine-1,4-diamide compound in preparation of medicines for treating and/or preventing inflammation reaction | 中国医学科学院医药生物技术研究所 | 2016-08-31 | — | — | CN | claimed |
| CN-105878247-A | Application of substituted piperazine-1,4-diamide compound to preparation of medicines for treatment and/or prevention of senescence | 中国医学科学院医药生物技术研究所 | 2016-08-24 | — | — | CN | claimed |
| CN-1228794-A | Polyamide composition for removing polyphenol in liquid | GRACE W R & CO (US) | 1999-09-15 | — | — | CN | claimed |
| CN-105902546-B | Application of the substituted piperazine -1,4- diamide compound in the medicine of preparation treatment and/or prevention of inflammation reaction | 中国医学科学院医药生物技术研究所 | 2019-01-18 | — | — | CN | disclosed |
| CN-105902546-B | Application of the substituted piperazine -1,4- diamide compound in the medicine of preparation treatment and/or prevention of inflammation reaction | 中国医学科学院医药生物技术研究所 | 2019-01-18 | — | — | CN | disclosed |
| CN-105902546-B | Application of the substituted piperazine -1,4- diamide compound in the medicine of preparation treatment and/or prevention of inflammation reaction | 中国医学科学院医药生物技术研究所 | 2019-01-18 | — | — | CN | disclosed |
| CN-105878247-B | Application of the substituted piperazine -1,4- diamide compound in preparation treatment and/or pre- anti-aging medicine | 中国医学科学院医药生物技术研究所 | 2018-11-16 | — | — | CN | disclosed |
| CN-105878247-B | Application of the substituted piperazine -1,4- diamide compound in preparation treatment and/or pre- anti-aging medicine | 中国医学科学院医药生物技术研究所 | 2018-11-16 | — | — | CN | disclosed |
| CN-105878247-B | Application of the substituted piperazine -1,4- diamide compound in preparation treatment and/or pre- anti-aging medicine | 中国医学科学院医药生物技术研究所 | 2018-11-16 | — | — | CN | disclosed |
| EP-2975038-B1 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES | VIIV HEALTHCARE UK(NO 4) LTD (GB) | 2017-07-12 | — | — | EP | disclosed |
| CN-104069109-B | Application of substituted piperazine-1, 4-diamide compound in pharmacy | 中国医学科学院医药生物技术研究所 | 2017-01-25 | — | — | CN | disclosed |
| US-20020119982-A1 | Antiviral azaindole derivatives | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2002-08-29 | — | — | US | disclosed |
| WO-2002062423-A1 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-15 | — | — | WO | disclosed |
| US-20020061892-A1 | Antiviral azaindole derivatives | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2002-05-23 | — | — | US | disclosed |
| EP-1140902-A1 | TRICYCLIC FARNESYL PROTEIN TRANSFERASE INHIBITORS | SCHERING CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140909-A1 | NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2001062255-A1 | ANTIVIRAL AZAINDOLE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-08-30 | — | — | WO | disclosed |
| WO-2000039119-A1 | NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |
| WO-2000037459-A1 | TRICYCLIC FARNESYL PROTEIN TRANSFERASE INHIBITORS | SCHERING CORPORATION (US) | 2000-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020119982-A1 | Antiviral azaindole derivatives | ZC3HAV1, MAVS, AZI2 | ALDH1A1 1054/4885HTT 2003/4885NPSR1 2414/4885 |
| US-20020061892-A1 | Antiviral azaindole derivatives | ZC3HAV1, MAVS, AZI2 | ALDH1A1 1054/4885HTT 2003/4885NPSR1 2414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.