Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.58 |
| ▸ | PPARD | Q03181 | 3/20 | 0.58 |
| ▸ | PPARG | P37231 | 12/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726752 | 0.95 | PPARA (0.60) | PPARAPPARDPPARGCYP4F2CYP4A11 | |
| SCHEMBL5727660 | 0.93 | PPARA (0.57) | PPARAPPARDPPARGCYP4F2CYP4A11 | |
| SCHEMBL5892294 | 0.86 | PPARA (0.46) | PPARAPPARDPPARGKMT2A | |
| SCHEMBL5892198 | 0.83 | PPARA (0.59) | PPARAPPARDPPARGKMT2ACYP1A2 | |
| SCHEMBL5660178 | 0.82 | PPARA (0.53) | PPARAPPARDPPARGCYP4F2CYP4A11 | |
| SCHEMBL14060871 | 0.82 | LMNA (0.64) | PPARAPPARDPPARGKMT2AMEN1 | |
| SCHEMBL5727498 | 0.81 | PPARG (0.62) | PPARAPPARDPPARGKMT2AMEN1 | |
| SCHEMBL5892268 | 0.81 | PPARA (0.47) | PPARAPPARDPPARGCYP1A2CYP2D6 | |
| SCHEMBL5659323 | 0.80 | PPARA (0.54) | PPARAPPARDPPARGCYP4F2CYP4A11 | |
| SCHEMBL5892173 | 0.79 | PPARA (0.60) | PPARAPPARDPPARGCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1502590-B1 | Heterocyclic oxime derivatives, process for their preparation and use thereof in the treatment of type II diabetes | SERVIER LAB (FR) | 2006-12-20 | — | — | EP | disclosed |
| EP-1502590-A1 | Heterocyclic oxime derivatives, process for their preparation and use thereof in the treatment of type II diabetes | Les Laboratoires Servier (FR) | 2005-02-02 | — | — | EP | disclosed |