Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726359 | 0.83 | DHFR (0.46) | DHFR | |
| SCHEMBL380792 | 0.82 | DHFR (0.67) | DHFR | |
| Hydrochloric Acid SCHEMBL8377343 | 0.81 | DHFR (0.65) | DHFR | |
| Water SCHEMBL28837029 | 0.81 | DHFR (0.65) | DHFR | |
| SCHEMBL5727148 | 0.79 | DHFR (0.55) | DHFR | |
| SCHEMBL5727329 | 0.79 | DHFR (0.49) | DHFR | |
| SCHEMBL31662914 | 0.79 | DHFR (0.49) | DHFR | |
| SCHEMBL5727145 | 0.79 | DHFR (0.49) | DHFR | |
| SCHEMBL30462085 | 0.78 | TKT (0.54) | DHFR | |
| SCHEMBL5727657 | 0.78 | PNP (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395568-B1 | 4-AMINOPYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-11-02 | — | — | EP | claimed |
| US-7138404-B2 | 4-aminopyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-11-21 | — | — | US | disclosed |
| EP-1395568-B1 | 4-AMINOPYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-11-02 | — | — | EP | disclosed |
| EP-1395568-A1 | 4-AMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-10 | — | — | EP | disclosed |
| US-20030022907-A1 | 4-aminopyrimidine derivatives | HOFFMANN-LA ROCHE INC. | 2003-01-30 | — | — | US | disclosed |
| WO-2002094795-A1 | 4-AMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-11-28 | — | — | WO | disclosed |
| EP-0046856-A2 | Process for preparing 4-amino-2-mercapto-pyrimidines | HÜLS TROISDORF AKTIENGESELLSCHAFT (DE) | 1982-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030022907-A1 | 4-aminopyrimidine derivatives | GRM5, GRIK5, GRM1 | DHFR 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.