Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739111 | 0.74 | AKT1 (0.41) | RECQLABCB1 | |
| SCHEMBL4924092 | 0.73 | ABCB1 (0.44) | RECQLABCB1CHRNA7KDM1AMAOB | |
| SCHEMBL14026296 | 0.73 | ABCB1 (0.44) | RECQLABCB1CHRNA7KDM1AMAOB | |
| SCHEMBL13376471 | 0.73 | ABCB1 (0.44) | RECQLABCB1CHRNA7KDM1AMAOB | |
| SCHEMBL2764590 | 0.73 | ABCB1 (0.44) | RECQLABCB1CHRNA7KDM1AMAOB | |
| SCHEMBL5728175 | 0.71 | GAA (0.44) | RECQLGAACYP2D6ALDH1A1KDM4E | |
| SCHEMBL10326487 | 0.70 | RECQL (0.46) | RECQLABCB1CHRNA7LMNAGAA | |
| SCHEMBL5728418 | 0.69 | TACR1 (0.36) | RECQLABCB1NR3C2LMNAGAA | |
| SCHEMBL7690874 | 0.69 | RAB9A (0.38) | ALDH1A1TSHRCACNA1D | |
| SCHEMBL14967416 | 0.68 | L3MBTL1 (0.42) | RECQLABCB1KDM1AMAOBRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | Aventis Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014555-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-02-17 | — | — | WO | disclosed |