Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | DNMT3B | Q9UBC3 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365498 | 0.85 | AR (0.70) | ARADORA3HSD11B1AKR1C3MAOB | |
| SCHEMBL15967952 | 0.81 | DNMT3B (0.45) | KDM4EHSD17B10DNMT3BMAPT | |
| SCHEMBL11561917 | 0.79 | CYP19A1 (0.48) | ARADORA3HSD11B1AKR1C3MAOB | |
| SCHEMBL11561915 | 0.79 | MAPT (0.47) | ARADORA3HSD11B1AKR1C3KDM4E | |
| 2'-Hydroxy-Flavanone SCHEMBL128288 | 0.77 | AR (1.00) | ARADORA3HSD11B1AKR1C3MAOB | |
| SCHEMBL1891296 | 0.77 | AR (0.68) | ARADORA3HSD11B1AKR1C3MAOB | |
| 2'-Hydroxy-Flavanone SCHEMBL128289 | 0.77 | AR (1.00) | ARADORA3HSD11B1AKR1C3MAOB | |
| SCHEMBL8093292 | 0.77 | ADORA3 (0.68) | ARADORA3HSD11B1AKR1C3MAOB | |
| 2'-Hydroxy-Flavanone SCHEMBL29661236 | 0.77 | AR (1.00) | ARADORA3HSD11B1AKR1C3MAOB | |
| SCHEMBL8093300 | 0.77 | ADORA3 (0.68) | ARADORA3HSD11B1AKR1C3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412343-B1 | COMPOUNDS, WHICH ARE POTENT INHIBITORS OF NA+/CA2+ EXCHANGE MECHANISM AND ARE USEFUL IN THE TREATMENT OF ARRHYTHMIAS | ORION CORP (FI) | 2006-08-30 | — | — | EP | disclosed |