Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BM
The experimentally established mechanism targets of Amantadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 known ✓ | Q05586 | 6/20 | 0.93 |
| ▸ | GRIN2A known ✓ | Q12879 | 6/20 | 0.93 |
| ▸ | GRIN2D known ✓ | O15399 | 5/20 | 0.93 |
| ▸ | GRIN3B known ✓ | O60391 | 5/20 | 0.93 |
| ▸ | GRIN2B known ✓ | Q13224 | 5/20 | 0.93 |
| ▸ | GRIN2C known ✓ | Q14957 | 5/20 | 0.93 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 5/20 | 0.93 |
| ▸ | LMNA | P02545 | 4/20 | 0.93 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.93 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.93 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.93 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.93 |
| ▸ | TSHR | P16473 | 1/20 | 0.93 |
| ▸ | STAT6 | P42226 | 1/20 | 0.93 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.93 |
| ▸ | THRB | P10828 | 2/20 | 0.87 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.87 |
| ▸ | POLB | P06746 | 1/20 | 0.87 |
| ▸ | BLM | P54132 | 1/20 | 0.87 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amantadine SCHEMBL28046544 | 1.00 | GRIN1 (0.93) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL28246033 | 0.97 | GRIN1 (0.87) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL20409394 | 0.96 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL21310017 | 0.96 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL4098 | 0.96 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL15532073 | 0.96 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL3642447 | 0.96 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL21309814 | 0.96 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL15672299 | 0.96 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Amantadine SCHEMBL23859927 | 0.93 | GRIN1 (0.93) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 219 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120041847-A | Method for electrochemical synthesis of hexamethylenediamine from acrylonitrile | 万华化学集团股份有限公司 | 2025-05-27 | — | — | CN | claimed |
| CN-118667138-A | Long-chain alkyl polycarbonate, synthesis method thereof and polycarbonate fiber | 浙江理工大学 | 2024-09-20 | — | — | CN | claimed |
| CN-118291998-A | Method for electrochemical co-production of adiponitrile and furoic acid | 万华化学集团股份有限公司 | 2024-07-05 | — | — | CN | claimed |
| CN-117185315-B | Method for preparing Cu-SSZ-39 molecular sieve | 天津派森新材料技术有限责任公司 | 2024-06-18 | — | — | CN | claimed |
| CN-118165221-A | Allophanate composition, polyisocyanate composition, and preparation methods and applications thereof | 万华化学（宁波）有限公司 | 2024-06-11 | — | — | CN | claimed |
| US-11883804-B2 | Method of making SSZ-13 zeolites with high acidity and low silica to alumina ratio (SAR) | PACIFIC INDUSTRIAL DEVELOPMENT CORPORATION (US) | 2024-01-30 | — | — | US | claimed |
| CN-112912340-B | Process for preparing SSZ-13 zeolite with high acidity and low silica to alumina ratio (SAR) | 太平洋工业发展公司 | 2024-01-02 | — | — | CN | claimed |
| CN-117185315-A | Method for preparing Cu-SSZ-39 molecular sieve | 天津派森新材料技术有限责任公司 | 2023-12-08 | — | — | CN | claimed |
| CN-114713041-B | Method for preparing Si-CHA molecular sieve membrane in situ | 南京工业大学 | 2023-09-29 | — | — | CN | claimed |
| CN-113716585-B | Method for preparing Cu-SSZ-13 molecular sieve by one-step method | 天津派森新材料技术有限责任公司 | 2023-06-13 | — | — | CN | claimed |
| CN-107511170-A | The preparation method of the molecular sieve catalyst of binderless ZSM-5 5 | 中国石油化工股份有限公司 | 2017-12-26 | — | — | CN | claimed |
| CN-107511165-A | The preparation method of binder free mercerising molecular sieve catalyst | 中国石油化工股份有限公司 | 2017-12-26 | — | — | CN | claimed |
| CN-107511169-A | The molecular sieve catalysts of ZSM 5, preparation method and application | 中国石油化工股份有限公司 | 2017-12-26 | — | — | CN | claimed |
| CN-107511163-A | Molecular sieve catalyst, preparation method and application | 中国石油化工股份有限公司 | 2017-12-26 | — | — | CN | claimed |
| CN-107511164-A | Y molecular sieve catalyst, preparation method and application | 中国石油化工股份有限公司 | 2017-12-26 | — | — | CN | claimed |
| CN-107497482-A | A kind of preparation and application of new type low temperature composite catalyst | 廊坊市北辰创业树脂材料有限公司 | 2017-12-22 | — | — | CN | claimed |
| CN-104803397-B | MCM-49 molecular sieve with low silica-alumina ratio, and preparation method thereof | 中国石油化工股份有限公司 | 2017-03-22 | — | — | CN | claimed |
| CN-106315610-A | Method for synthesizing CHA molecular sieve through ultrasonic pretreatment of coal gangue | 天津大学 | 2017-01-11 | — | — | CN | claimed |
| US-20160297782-A1 | CATALYST PERFORMANCE IN PROPYLENE EPOXIDATION | LYONDELL CHEMICAL TECHNOLOGY, L.P. (US) | 2016-10-13 | — | — | US | claimed |
| WO-2016164585-A1 | IMPROVED CATALYST PERFORMANCE IN PROPYLENE EPOXIDATION | LYONDELL CHEMICAL TECHNOLOGY, L.P. (US) | 2016-10-13 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297782-A1 | CATALYST PERFORMANCE IN PROPYLENE EPOXIDATION | AOC2, AOC3, AOX1 | GRIN1 3906/4885GRIN2A 4121/4885GRIN2D 3797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.