Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.36 |
| ▸ | GAK | O14976 | 2/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.36 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.36 |
| ▸ | STK36 | Q9NRP7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728276 | 0.87 | CHEK1 (0.40) | CHEK1GABRA5JAK2MAPK14GAK | |
| SCHEMBL5728057 | 0.85 | GABRA5 (0.38) | CHEK1GABRA5GAKMAPK1 | |
| SCHEMBL5434890 | 0.84 | CHEK1 (0.44) | CHEK1GABRA5JAK2MAPK14GAK | |
| SCHEMBL5728400 | 0.75 | ACKR3 (0.32) | JAK2ACKR3ADORA2A | |
| SCHEMBL5727996 | 0.75 | JAK2 (0.40) | CHEK1JAK2 | |
| SCHEMBL5728398 | 0.74 | JAK2 (0.38) | CHEK1JAK2ADORA2A | |
| SCHEMBL6112105 | 0.71 | ALDH1A1 (0.37) | GAKMAPK1MAPK10 | |
| SCHEMBL5435719 | 0.70 | IKBKB (0.46) | CHEK1JAK2 | |
| SCHEMBL5728483 | 0.69 | ACKR3 (0.33) | CHEK1JAK2MAPK1ACKR3 | |
| SCHEMBL5728485 | 0.68 | ALDH1A1 (0.41) | CHEK1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694665-A2 | SUBSTITUTED THIOPHENES | AiCuris GmbH & Co. KG (DE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005063734-A2 | SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2005-07-14 | — | — | WO | disclosed |