Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5727459 | 0.93 | POLB (0.36) | TP53KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL5430593 | 0.87 | ALDH1A1 (0.39) | TP53KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL5430588 | 0.87 | ALDH1A1 (0.39) | TP53KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL5727999 | 0.85 | ALDH1A1 (0.34) | KMT2AALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL5728027 | 0.85 | GABRA1 (0.32) | — | |
| SCHEMBL5441564 | 0.83 | POLB (0.38) | TP53KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL5441559 | 0.83 | POLB (0.38) | TP53KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL5728218 | 0.79 | CUL4A (0.33) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5728467 | 0.78 | ALDH1A1 (0.33) | KMT2AALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL5728575 | 0.77 | GABRA1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694665-A2 | SUBSTITUTED THIOPHENES | AiCuris GmbH & Co. KG (DE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005063734-A2 | SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2005-07-14 | — | — | WO | disclosed |