Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | IKBKB | O14920 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.45 |
| ▸ | TUBB | P07437 | 3/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728563 | 0.85 | MAPT (0.61) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL27712944 | 0.81 | MAPT (0.56) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL5728267 | 0.81 | ALDH1A1 (0.64) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL1799511 | 0.78 | GAA (0.72) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL15681582 | 0.75 | MAPT (0.52) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL9573004 | 0.72 | FABP3 (0.47) | MAPTGAAALDH1A1HPGDALOX15 | |
| SCHEMBL27821730 | 0.71 | ELANE (0.46) | MAPTALDH1A1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL5728244 | 0.71 | IKBKB (0.56) | MAPTGAAALDH1A1HPGDMEN1 | |
| Biphenyl SCHEMBL28089702 | 0.70 | ELANE (0.46) | MAPTGAAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL14894503 | 0.70 | ELANE (0.47) | MAPTGAAALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694665-A2 | SUBSTITUTED THIOPHENES | AiCuris GmbH & Co. KG (DE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005063734-A2 | SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2005-07-14 | — | — | WO | disclosed |